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Determination of IC50 values for inhibition of OCT2-mediated MPP transport produced by eight OCT2 substrates and four inhibitors of OCT2-mediated transport. Each figure shows inhibition of [3H]MPP transport (∼10 nM; 30-second uptake), expressed as percentage of control uptake, averaged for two to six separate experiments for each inhibitor (see Table 2). The listed IC50 values reflect the average of the values obtained in the individual experiments with each test agent.
