TABLE 1.

Summary of experiments

Experiment	Experimental Test	Drug	Doses	Route	Ambient Temperature	Sample Size
1	Diet and oxygen consumption	CHA	0.5 mg/kg	i.p.-Bolus	16°C	15
2	↑ Dose of CHA	CHA	1.0 mg/kg	i.p.-Bolus	17°C	10
	Compare partial agonist	Capadenoson	1.0 and 2.0 mg/kg	i.p.-Bolus	17°C	10
3	Surface temperature modulation with i.v. CHA	CHA	0.25 mg/kg/h	i.v.-Continuous	16°C–32°C	2