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. 2005 Feb 11;5:7. doi: 10.1186/1472-6750-5-7

Table 10.

Comparing variances of spot intensities when using multiple values to impute versus a single value imputation.

Multiple Imputation Single Imputation
Treatment Control Treatment Control

SSP 1509 0.767 0.663 7.05 8.39 9 missing control
Range = (3.16) Range = (2.63) Range = (7.34) Range = (6.56) 3 missing treatment
SSP 1733 0.356 1.4249 0.356 1.4249 0 missing control
Range = (2.23) Range = (3.74) Range = (2.23) Range = (3.74) 0 missing treatment
SSP 6314 1.2055 1.178 3.41 1.17 0 missing control
Range = (3.94) Range = (3.51) Range = (7.15) Range = (3.51) 14 missing treatment
SSP 6452 0.547 0.564 0.547 0 15 missing control
Range = (2.79) Range = (2.14) Range = (2.79) Range = (0) 0 missing in treatment

The variances for spots with missing values are either under estimated or over estimated with single imputation values. The ranges and variance values of intensities are closer to that of SSP 1733 (spot with no missing intensities) in the case of multiple value imputation.