Table 3. Sensitivity Analyses for Concurrent Associations Between Attention-Deficit/Hyperactivity Disorder Medication Use and Motor Vehicle Crash (MVC) Events.
| Variable | No. of Patients | No. of MVC Events | Within-Individual Odds Ratio (95% CI) |
|---|---|---|---|
| Men | |||
| With no other psychiatric medication | 535 547 | 1854 | 0.56 (0.48-0.66) |
| With no psychotherapy | 820 100 | 3350 | 0.61 (0.55-0.69) |
| Incident diagnosis cohort | 215 134 | 1146 | 0.66 (0.54-0.82) |
| Incident diagnosis cohort and first MVC event only | 215 134 | 1115 | 0.45 (0.36-0.57) |
| Age group, y | |||
| 18-25 | 522 667 | 3271 | 0.61 (0.55-0.69) |
| 26-35 | 236 249 | 897 | 0.61 (0.49-0.76) |
| 36-45 | 174 849 | 642 | 0.69 (0.53-0.89) |
| ≥46 | 187 288 | 591 | 0.56 (0.43-0.73) |
| Full cohort, excluding the last month before disenrollment | 1 081 258 | 5116 | 0.62 (0.57-0.68) |
| Patients with index dates 2005-2009 | 430 827 | 2057 | 0.70 (0.61-0.82) |
| Patients with index dates 2010-2014 | 690 226 | 3344 | 0.57 (0.51-0.64) |
| Full cohort with 1-mo extended medication periods | 1 121 053 | 5401 | 0.65 (0.59-0.71) |
| Full cohort with stimulant medication as exposure only | 1 121 053 | 5401 | 0.63 (0.57-0.69) |
| Full cohort with ED visit of injured motorcyclist as outcome | 1 121 053 | 2297 | 0.61 (0.53-0.70) |
| Full cohort with any MVC as outcome | 1 121 053 | 10 003 | 0.61 (0.57-0.66) |
| Full cohort with SSRIs as exposure | 1 121 053 | 5401 | 0.93 (0.82-1.08) |
| Women | |||
| With no other psychiatric medication | 356 918 | 1154 | 0.51 (0.42-0.63) |
| With no psychotherapy | 831 922 | 3526 | 0.54 (0.48-0.60) |
| Incident diagnosis cohort | 203 298 | 1190 | 0.72 (0.59-0.87) |
| Incident diagnosis cohort and first MVC event only | 203 298 | 1166 | 0.54 (0.44-0.66) |
| Age group, y | |||
| 18-25 | 416 248 | 2830 | 0.61 (0.54-0.68) |
| 26-35 | 266 275 | 1244 | 0.56 (0.46-0.67) |
| 36-45 | 241 620 | 1064 | 0.53 (0.44-0.65) |
| ≥46 | 274 254 | 956 | 0.54 (0.44-0.66) |
| Full cohort, excluding the last month before disenrollment | 1 155 584 | 5735 | 0.58 (0.53-0.63) |
| Patients with index dates 2005-2009 | 415 605 | 2114 | 0.60 (0.53-0.69) |
| Patients with index dates 2010-2014 | 781 792 | 3980 | 0.56 (0.50-0.61) |
| Full cohort with 1-mo extended medication periods | 1 198 397 | 6094 | 0.58 (0.53-0.63) |
| Full cohort with stimulant medication as exposure only | 1 198 397 | 6094 | 0.59 (0.54-0.64) |
| Full cohort with ED visit of injured motorcyclist as outcome | 1 198 397 | 3478 | 0.51 (0.46-0.57) |
| Full cohort with ambulance, inpatient, or emergency MVC as outcome | 1 198 397 | 11 314 | 0.63 (0.59-0.66) |
| Full cohort with SSRIs as exposure | 1 198 397 | 6094 | 0.77 (0.69-0.86) |
Abbreviations: ED, emergency department; SSRIs, selective serotonin reuptake inhibitors.