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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Pain. 2017 Aug;158(8):1586–1598. doi: 10.1097/j.pain.0000000000000961

Figure 1. Neonatal mouse model of repetitive sucrose exposure given for procedural pain.

Figure 1

(A) Representative images showing C57Bl/6J mouse pups receiving oral sucrose treatment preceding 10 interventions daily: Handle, Tactile or Needle-prick. Ecchymosis and inflamed paws are highlighted by white circles showing focal needle-prick intervention effects. (B) Experimental protocol illustrating treatment/intervention timeline. Brain tissue was collected between P85–P95 for 7T MRI scanning. (C) Neonatal mice (n = 109) were assigned randomly across treatment/intervention groups (total of 6 groups). Distribution, mean weight gain over treatment period, mean body weight at MRI scan, sex ratio and survival amongst groups during the current study are provided.