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Micelleplexes were assembled via BR (batch reactor) and MF (microfluidic mixing) at an N/P ratio of 6. Both formulations were tested at N/P 6 and incubated in the presence of heparin for 30 min at pH 7.4 or 4.5. This heparin assay at pH 7.4 mimics the pH during in vivo circulation while pH 4.5 mimics the late endosome acidic environment. Free siRNA represents 100% siRNA release.
