Schematic representation of hydrogen sulfide synthesis and degradation. CβS, Cystationine β-synthase; CSE, Cystathionine γ-lyase; 3-MST, 3-mercaptopyruvate sulfurtransferase; CAT, cysteine aminotransferase; PLP, pyridoxal-5′-phosphate, GSSG, oxidized glutathione, GSH, reduced glutathione, R-SH, thiol-bearing intermediate; SO, sulfite oxidase; and TSMT, thiol S-methyltransferase.