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. Author manuscript; available in PMC: 2018 Jul 5.
Published in final edited form as: Cell Metab. 2017 Jun 22;26(1):39–48. doi: 10.1016/j.cmet.2017.05.016

Figure 4. Mitochondrial and metabolic profiles of stem cells versus differentiated cells.

Figure 4

ESCs have less reliance on mitochondrial metabolism, and this is reflected in the ultrastructure of their mitochondria. Similar differences exist when somatic cells are reprogrammed into iPSCs. As noted in the main text, these generalizations for mitochondrial structure in stem cells do not apply to neural stem cells. ROS and calcium are two regulators of differentiation that are regulated by mitochondrial function.