Table. Conscious Sedation vs Elective GA: Baseline Characteristics, Procedural Variables, and Outcomes.
| Characteristic | No. (%) | P Value | |
|---|---|---|---|
| Conscious Sedation (n = 61) |
Elective GA (n = 61) |
||
| Age, median (IQR), y | 69 (60-75) | 67 (55.5-78.5) | .83a |
| Glucose, median (IQR), mg/dL | 121 (108-153) | 129 (113.157.5) | .46a |
| bNIHSS, mean (SD) | 15.20 (7.32) | 17.47 (9.31) | .40a |
| Sex, male | 33 (54.1) | 25 (41) | .44 |
| Hypertension | 43 (70.5) | 39 (63.9) | .21 |
| Dyslipidemia | 26 (42.6) | 26 (42.6) | .17 |
| Atrial fibrillation | 14 (23) | 13 (21.3) | .80 |
| Diabetes | 12 (19.7) | 14 (23) | .65 |
| Smoking | 18 (29.5) | 18 (29.5) | .99 |
| Hemoglobin A1c, median (IQR), % of total hemoglobin | 5.8 (5.5-6.2) | 5.8 (5.5-6.2) | .90 |
| LDL cholesterol, median (IQR), mg/dL | 91 (66-113) | 89 (68.5-117.5) | .70 |
| Creatinine, median (IQR), mg/dL | 0.9 (0.8-1.1) | 0.99 (0.7-1.1) | .89 |
| Platelets, median (IQR) | 230 (181-257) | 208 (180-280) | .69 |
| INR, median (IQR) | 1.1 (1.0-1.2) | 1.05 (1.0-1.2) | .96 |
| Baseline SBP, mean (SD), mm Hg | 157.38 (28.26) | 147.64 (27.25) | .19 |
| IV thrombolyis | 8 (13.8) | 14 (23.7) | .10 |
| Etiology | |||
| Cardioembolic | 22 (36.1) | 20 (32.8) | .73 |
| Large vessel atherosclerosis | 19 (31.9) | 24 (39.3) | |
| Other determined etiology | 4 (6.6) | 4 (6.6) | |
| Undetermined | 16 (26.2) | 13 (21.3) | |
| Procedure | |||
| LKN to puncture, median (IQR) | 620 (266-1306) | 567 (316-846.5) | .56 |
| LKN to reperfusion, median (IQR) | 703 (357-1510) | 705 (408-1157) | .48 |
| Procedure length, median (IQR)b | 99 (61-135) | 86.5 (67-126) | .77 |
| Conversions | 8 (13.1) | NA | NA |
| Stentriever | 23 (37.7) | 19 (31.1) | .49 |
| Penumbra aspiration | 7 (11.5) | 10 (16.7) | .46 |
| Merci retriever | 11 (18) | 13 (21.3) | .63 |
| Intracranial stenting | 16 (26.7) | 18 (29.5) | .67 |
| Reperfusion | |||
| mTICI 2b-3 | 53 (86.9) | 54 (88.5) | .78 |
| mTICI 3 | 30 (49.2) | 32 (52.5) | .72 |
| Wire perforation | 4 (6.6) | 3 (4.9) | .99 |
| Any PH | 6 (9.8) | 6 (9.8) | .99 |
| mRS 0-2 at 90 d | 23 (38.3)c | 19 (31.1) | .23 |
| Mortality at 90 d | 21 (35)c | 26 (42.6) | .33 |
Abbreviations: bNIHSS, baseline National Institutes of Health Stroke Scale score; GA, generalized anesthesia; INR, international normalized ratio; IV, intravenous; LDL, low-density lipoprotein; LKN, last known normal; mRS, modified Rankin scale score; mTICI, modified thrombolysis in cerebral infarction score; NA, not applicable; PH, parenchymal hematoma; SBP, systolic blood pressure.
SI conversion factors: To convert creatinine to micromoles per liter, multiply by 88.4; to convert glucose to millimoles per liter, multiply by 0.0555; to convert hemoglobin A1c to proportion of total hemoglobin, multiply by 0.01; to convert LDL cholesterol to millimoles per liter, multiply by 0.0259.
Control individuals were matched for these criteria.
Procedure length: time from groin puncture to reperfusion or last run if reperfusion not achieved. Intubation time included for the converted monitored anesthesia care cases.
n = 60.