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FOXO1 inhibition reverses CIH-induced cardiac apoptosis. (A) TUNEL staining of LV myocardium in CIH and CIH-treated with FOXO1 inhibition AS1842856 (magnification, 400×). (B) TUNEL-positive cells are significantly increased in the rats exposed to CIH, whereas these cells are significantly decreased by injection of FOXO1 inhibitor AS1842856. * P<0.05, ** P<0.01 compared with control, n=6. (NC, Normoxia group; T, AS1842856.)
