Reduced levels of 120-kDa serum SIRT1 (s120S) protein in COPD. A, s120S protein level in serum from healthy subjects and subjects with COPD (NS + SM) (C1-4 disease stage). Protein levels of (B) 102-kDa and (C) 75-kDa SIRT1 with or without COPD. D, Correlation between the s120S protein level and FEV1/FVC ratio. E, Correlation between the s120S protein level and FEV1 % predicted. F, s120S protein levels of healthy subjects and patients with COPD (NS + SM) of different stages (C1-2, C3-4). NS = nonsmoking subjects; PC = positive control from healthy subject; SM = smokers without COPD.