Table 3. Outcomes of Open, Robotic, and Laparoscopic TPIATs.
| Source | No. of Patients | Operation | Mean Operative Time, min | Mean Islet Isolation Time, min | Mean Islet Count, IE/kg | Mean EBL, mL | No. of Patients Requiring Blood Transfusions/Total No. of Patients (%) | Mean LOS, d | No. of Deaths Before Initial Discharge | No. of Patients With Pain Control at Follow-up/Total No. of Patients (%) | No of Patients With Controlled Glucose at Follow-up/Total No. of Patients (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Desai et al, 2011 | 12 | Open TPIAT | 637.2 | ≥250 | 2538.2a | 641.7 | 6/12 (50) | 16 | 0 | NR | NR |
| Ahmad et al, 2005 | 45 | Open TPIAT | 533 | Approximately 240 | 3799 in ID patients 6635 in II patients |
563 | 24/45 (53) | 12.6 | 0 | 23/32 (72) Opioid independent at 23-mo follow-upb | 18-mo Follow-up: 18/45 (40) at insulin dose of 0 U/d, 11/45 (24) at 1-20 U/d, 9/45 (20) at 21-40 U/d, and 7/45 (16) at >40 U/d |
| Sutherland et al, 2012 | 409 | Open TPIAT | NR | 270a | 3260a in last 253 cases | NR | NR | NR | 5 | 186/207 (90) With preoperative opioid use, 122/207 (59) opioid independent at 24-mo follow-up |
36-mo Follow-up at <2500 IE/kg transplanted: 4/33 (12) II, 11/33 (33) PF, and 18/33 (55) ID; at 2500-5000 IE/kg transplanted: 8/37 (22) II, 23/37 (62) PF, and 6/37 (16) ID; and at >5000 IE/kg transplanted: 18/25 (72) II, 6/25 (24) PF, and 1/25 (4) ID patients |
| Galvani et al, 2014 | 6 | Robotic TPIAT | 712 | 272.6 | 2301 | 630 | 1/6 (17) | 12.6 | 0 | All 5/5 (100) patients with intractable chronic pain syndrome were in the process of successfully weaning off narcotics at 1 mo follow-up | NR |
| Current study | 20 | Laparoscopic TPIAT | 493 | 185 | 1325c | 627.5 | 3/20 (15) | 11 | 0 | 17/20 (85) With preoperative opioid use, 12/20 (60) opioid independent at 6-mo follow-up |
12.5-mo Follow-up: 5/20 (25) at insulin dose of 0 U/g, 9/20 (45) at 1-10 U/d, 5/20 (25) at 11-20 U/d, and 1/20 (5) at >20 U/d |
Abbreviations: EBL, estimated blood loss; ID, insulin dependent; IE, islet equivalent; II, insulin independent; LOS, length of stay; NR, not reported; PF, partial function; TPIAT, total pancreatectomy with islet autotransplantation.
a
Reported as median.
b
Subset of patients with longer than 5 mo of follow-up (n = 32).
c
Represents mean IE count in the 4 patients most recently undergoing laparoscopic TPIAT.