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3D structure of the humanized V-domains of ACT017 (VL8b and VH3 variants). (A) Stereo view with colored CDRs. Mutated residues exposed at the surface are in cyan. (B) VL domain with residues buried at the interface with VH in light pink. (C) VH domain with residues buried at the interface with VL in light green. (D) VH domain with the 2 mutated residues from CDR H2 in cyan.
