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. 2017 Jun 9;9(6):945–958. doi: 10.1080/19420862.2017.1336592

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© 2017 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 6. — Overview of immunogenic potential of ACT017. (A) Putative T-cell epitope cluster found in ACT017 V-domains and main features. Clusters highlighted in green contain known Tregitope sequences. Cluster highlighted in blue contains homolog to known Tregitopes sequences. (B) Immunogenicity scale (Epimatrix protein score). Upper pane showcases: observed ADA responses in known antibodies. Lower pane showcases: predicted ADA responses in ACT017. All predictions are adjusted for the presence of Tregitopes.