Figure 8.

Effects of escalating doses of ACT017 on ex vivo collagen-induced blood platelet aggregation, GPVI expression level and bleeding time in 4 cynomolgus monkeys. (A) Mean intensity of collagen-induced platelet aggregation is expressed as a percent of light transmission. (B) GPVI expression level analyzed after immunolabeling with FITC-conjugated anti-human GPVI monoclonal antibody of blood samples and fluorescence measurement. (C) Average bleeding time evolution during the study. Average bleeding time at 30 min after injection of abciximab is out of the scale (> 30 min). Animals were treated with vehicle (gray triangle), ACT017 at 1 mg/kg (black circle), 2 mg/kg (blue), 4 mg/kg (red) and 8 mg/kg (green).