Figure 4.

CALY-002 effect on spleen and intestinal intra-epithelial lymphocyte subsets in IL-15 transgenic mice. Total number of (A) spleen and intestinal intra-epithelial (B) CD3⁺CD8⁺, CD3⁺CD4⁺, CD3⁻CD19⁺, CD45⁺CD3⁻NK1.1 and TCRαβ⁺NK1.1⁺ lymphocytes at Day 28. Symbols represent individual IL-15 transgenic mice treated with either CALY-002 (closed circles) or control isotype (open squares) antibodies, or control C57BL/6 mice (closed triangles). Results are expressed as mean ± SD of absolute cell number/μL for a 1 mL suspension per animal. Statistical analysis: Student's t test. *p < 0.05; **p < 0.01; ***p < 0.001; ns: not significant.