Table 3.

Multivariate analysis of the relationship between each comorbidity and ED diagnosis or treatment in MarketScan claims database and Humedica EHR database

	Regression Coefficient (SE)	Odds Ratio* (95% CI)
MarketScan Claims Database
Hypertension	0.6324 (0.00271)	1.882† (1.872–1.892)
Other cardiovascular disease‡	−0.4873 (0.004)	0.614† (0.610–0.619)
Diabetes mellitus	0.2839 (0.00333)	1.328† (1.320–1.337)
Depression	0.3202 (0.00488)	1.377† (1.364–1.391)
Benign prostatic hyperplasia	0.8991 (0.00379)	2.457† (2.439–2.476)
Humedica EHR Database
Hypertension	1.084 (0.005)	2.956† (2.928–2.985)
Other cardiovascular disease‡	−0.403 (0.007)	0.669† (0.660–0.677)
Diabetes mellitus	0.331 (0.006)	1.393† (1.376–1.410)
Depression	0.442 (0.008)	1.555† (1.532–1.579)
Benign prostatic hyperplasia	1.110 (0.007)	3.033† (2.990–3.076)

Multivariate logistic regression analysis adjusted for age, baseline variables, and year and month of index date.

^*Estimated odds of ED diagnosis or treatment relative to men without the comorbidity (odds ratio=1).

^†2-sided P <0.0001.

^‡Other cardiovascular disease included stroke, myocardial infarction and angina, coronary heart disease, and congestive heart failure.

ED=erectile dysfunction; EHR=electronic health records.