Table 2.

Gene ontology category enrichment of differentially abundant proteins

GO term	Description	FDR q-valuea)	Fold enrichmentb)	No. of proteinsc)
Molecular function
GO:0004888	Transmembrane signaling receptor activity	2.56E–08	6.82	20
GO:0004872	Receptor activity	1.77E–08	4.74	27
GO:0038023	Signaling receptor activity	8.73E–08	5.69	21
GO:0060089	Molecular transducer activity	5.27E–06	3.2	31
GO:0004871	Signal transducer activity	2.94E–05	3.36	26
GO:0005102	Receptor binding	4.46E–05	2.64	35
Cellular component
GO:0005576	Extracellular region	3.47E–11	5.1	30
GO:0005765	Lysosomal membrane	5.97E–03	3.5	13
GO:0005768	Endosome	4.36E–03	2.69	20
GO:0005886	Plasma membrane	7.61E–09	2.2	67
GO:0010008	Endosome membrane	1.04E–04	3.52	20
GO:0016021	Integral component of membrane	8.60E–31	3.26	105
GO:0043235	Receptor complex	1.29E–05	5.86	14

^a)Cut-off chosen was a false discovery rate <0.001.

^b)Fold enrichment is with respect to all proteins quantified in the dataset.

^c)Number of proteins with altered abundance (≥1.5-fold) in our dataset that were classified in a given category.