Fig. 4.

Antidepressants and ω-3 fatty acids modulate changes of kynurenine pathway metabolites caused by IL-1β treatment. Co-treatment of cells with IL-1β and ω-3 fatty acids partially abrogated the increase in kynurenine caused by the cytokine (a). Co-treatment with sertraline fully reverted the decrease in levels of ANA caused by IL-1β (b). Co-incubation with DHA and sertraline partially reverted the increase in QUIN levels caused by IL-1β (c). No significant changes in PIC were observed by any co-incubation (d); ^*p < 0.05, ^**p < 0.001.