Table E2.
Subjects' characteristics for esRAGE ELISA
| Characteristic | Healthy control (n = 15) |
Asthma mild-moderate (n = 16) |
Asthma severe (n = 19) |
ANOVA/χ2 test∗ |
|---|---|---|---|---|
| GINA classification, n | GINA 1, n = 4 GINA 2, n = 2 GINA 3, n = 10 |
GINA 4, n = 12 GINA 5, n = 7 |
||
| Age (y)† | 53.1 ± 3.9 | 58.2 ± 3.7 | 59.6 ± 2.5 | P = .37 |
| Sex: male, n (%) | 7 (46.7) | 8 (50) | 10 (52.6) | P = .94∗ |
| Atopy, n (%) | 4 (26.7) | 9 (56.25) | 15 (78.9) | P = .01∗ |
| Smoking status, current smoker, n (%) | 0 (0) | 1 (6.25) | 3 (15.8) | P = .23∗ |
| ICS (μg/d BDP equivalent)‡ | 0 (0) | 200 (400) | 2000 (400)§|| | P < .001 |
| Pre-BD FEV1 % predicted‡ | 94.0 (50.5) | 86.5 (32.3) | 75.0 (16.0)§ | P = .030 |
| Pre-BD FEV1/FVC‡ | 75.0 (6.0) | 73.5 (13.8) | 72.0 (14.0) | P = .09 |
| % Sputum neutrophils† | 62.3 ± 5.8 | 59.5 ± 7.0 | 59.4 ± 4.6 | P = .93 |
| % Sputum eosinophils‡ | 0.75 (1.96) | 0.75 (1.75) | 4.25 (13.3)§|| | P = .001 |
| % Sputum epithelial cells‡ | 1.2 (2.1) | 1.5 (4.8) | 1.5 (3.0) | P = .90 |
Samples used are subsets of those used for the HMGB1 ELISA.
BDP, Beclometasone dipropionate; esRAGE, endogenous secretory RAGE; ICS, inhaled corticosteroid; FVC, forced vital capacity; pre-BD, prebronchodilator.
∗
χ2 test.
†
Mean ± SEM.
‡
Median (interquartile range).
§
P < .05 vs healthy control.
||
P < .05 vs mild asthma.