Table E3.
Subjects' characteristics for immunohistochemistry
| Characteristic | Healthy control (n = 10) |
Asthma severe (n = 19) |
t test/χ2 test∗ |
|---|---|---|---|
| GINA classification, n | GINA 4, n = 11 GINA 5, n = 5 |
||
| Age (y)† | 46.7 ± 6.2 | 55 ± 2.8 | P = .17 |
| Sex: male, n (%) | 5 (50) | 8 (42.1) | P = .71∗ |
| Smoking status, current smoker, n (%) | 1 (10) | 5 (26.3) | P = .63∗ |
| ICS (μg/d BDP equivalent)‡ | 0 (0) | 1600 (125)§ | P < .001 |
| Pre-BD FEV1 % predicted‡ | 93.5 (28.6) | 76.0 (54.7) | P = .065 |
| Pre-BD FEV1/FVC‡ | 90.5 (13.3) | 71.1 (24.9)§ | P = .0009 |
| % Sputum neutrophils† | 50.5 ± 18.7 | 52.6 ± 6.1 | P = .9 |
| % Sputum eosinophils‡ | 0.4 (0.8) | 5.3 (16.8)§ | P = .002 |
BDP, Beclometasone dipropionate; ICS, inhaled corticosteroids; FVC, forced vital capacity; pre-BD, pre-bronchodilator.
∗
χ2 test.
†
Mean ± SEM.
‡
Median (interquartile range).
§
P < .05 vs healthy control.