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. 2017 Aug 2;3(8):e1700810. doi: 10.1126/sciadv.1700810

Fig. 2. Extracellular acidification strongly potentiates BmP01 in activating TRPV1 and inducing pain.

Fig. 2

(A) Determination of the acidity value of venom from M. martensii. (B) Comparison of the acidity value of different venoms. (C) Representative whole-cell currents from hTRPV1 at various BmP01 concentrations and pH levels. (D) Concentration-response relationships of BmP01 at various pH levels fitted to a Hill equation; n = 5 to 10. (E) Paw-licking behavior of mice following injection of either saline, BmP01 (pH 7.0 or 6.5), or capsaicin (pH 7.0 or 6.5). Ten microliters of each reagent was injected at the plantar surface of the left hind paw. NS, not significant. **P < 0.01.