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. 2017 Aug 2;3(8):e1700810. doi: 10.1126/sciadv.1700810

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Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 3 — (A) Schematic representation of the chimeras between mTRPV1 (blue) and mTRPV3 (red), and mTRPV1 mutants containing a sequence replacement in the turret (yellow). (B) Comparison of the BmP01 response (shown as percentage of the capsaicin response). mTRPV1 was used as wild type (WT). **P < 0.001 (n = 3 to 5). (C) Concentration-response relationships of WT mTRPV1, V_1/3S, and V_1/3L fitted to a Hill equation. (D) Comparison of the BmP01 response of WT hTRPV1 and point mutants. **P < 0.001 (n = 3 to 5). (E) Representative whole-cell current recording from hTRPV1 treated with BmP01 and its point mutants (200 μM each) and 3 mM 2APB. (F) Concentration-response relationships for WT BmP01 and K23A fitted to a Hill equation (n = 5 to 10).