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Schematic graph shows hypothetical mechanisms for cAMP and cGMP in regulation of anodal migration of cell fragments. Two biased signals determine the migration direction in an EF. Myosin-dependent pathway dominates in cell fragments and dictates the migration direction to the anode. cAMP and cGMP could regulate the directional signaling balance which controls galvanotaxis of cell fragments by inhibiting anodal signal and activating cathodal signal simultaneously.
