Table 3.
In vitro skin permeation parameters of PR following topical application of ethosome, liposome, 20% PG solution, and 30% hydroethanolic solution formulations.
| Formulations | J ss (µg/cm2/h) | K p (×10−3 cm/h) | T lag (h) |
|---|---|---|---|
| Ethosome | 2.60 ± 0.27a | 0.52 ± 0.05a | 6 ± 0.63a |
| Liposome | 0.96 ± 0.42b | 0.19 ± 0.08b | 7 ± 1.50a |
| PG solution | 2.95 ± 0.42a,c | 0.59 ± 0.08a,c | 5 ± 0.49a |
| 30% hydroethanolic solution | 3.77 ± 0.31c | 0.75 ± 0.06c | 4 ± 0.40a |
Each data represents the mean ± SEM (n = 5). Jss, steady state flux; Kp, permeability coefficient; Tlag, lag time. a–c: means in the same column with different superscript letter differ significantly (P < 0.05).