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mTOR inhibition alleviates oxidative stress in human gingival fibroblasts. (a) FACS analysis of reactive oxygen species (ROS) levels in low-passage hGFs and high-passage hGFs pretreated or not (control) with rapamycin after 3 or 30 days. (b) The results of real-time PCR show the mRNA expression of antioxidant components Cat, Sod2, and Prdx3 (∗ means P < 0.05, compared with the high-passage group).
