Fig 5. B. abortus RNA is able to down-modulate MHC-I on primary cultures of monocytes/macrophages.

(A and B) Peripheral blood-isolated human monocytes (A) and murine bone marrow-derived macrophages (BMM) (B) were treated with different doses of B. abortus RNA. MHC-I expression was assessed by flow cytometry. Bars represent the arithmetic means ± SEM of five experiments. MFI, mean fluorescence intensity; mIFN-γ, murine IFN-γ. ***P<0.001 vs. IFN-γ-treated.