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. Author manuscript; available in PMC: 2017 Aug 2.
Published in final edited form as: Handb Exp Pharmacol. 2015;226:219–235. doi: 10.1007/978-3-662-44605-8_13

Fig. 3.

Fig. 3

DRG cells from AEW-treated mice show enhanced responses to PAR-2 agonist and 5-HT but not histamine. (a) Histamine. Mean normalized ratiometric responses of DRG cells from each treatment group vs. time relative to histamine perfusion (red bar). Error bars: SEM. (b) Mean peak response (% change from baseline) of DRG cells to histamine for each treatment group. N.s.: no significant difference compared to W. (c, e) as in (a) for PAR-2 agonist and 5-HT, respectively. (d, f) as in (b) for PAR-2 agonist and 5-HT, respectively. Asterisk, significantly different compared to W (p < 0.05, unpaired t-test). (n = 14–23/group). Naïve data from cervical DRG cells (n = 719) obtained from untreated mice. Adapted from Akiyama et al. (2010a)