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. Author manuscript; available in PMC: 2017 Aug 2.
Published in final edited form as: Handb Exp Pharmacol. 2015;226:219–235. doi: 10.1007/978-3-662-44605-8_13

Fig. 4.

Fig. 4

Nerve growth factor (NGF) sensitizes cowhage- but not histamine-induced itch. Itch sensation recorded upon (a) histamine iontophoresis and (b) cowhage spicule insertion at day 7 (left panel) and day 21 (right panel) after administration of 1 µg NGF (n = 12). In comparison with control skin, cowhage-induced itch was perceived significantly stronger at the NGF-treated sites at day 21 (marked by asterisks, Wilcoxon test, P < 0.05). Gray bars indicate the time point of histamine iontophoresis and gray cowhage application. Error bars indicate SEM. VAS, visual analog scale. Adapted from Rukwied et al. (2013)