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. Author manuscript; available in PMC: 2017 Aug 2.
Published in final edited form as: Handb Exp Pharmacol. 2015;226:219–235. doi: 10.1007/978-3-662-44605-8_13

Fig. 5.

Fig. 5

Scratching and alloknesis elicited by different pruritogens. (a) Dose-response curve for scratch bouts (assessed over 30 min) elicited by intradermal injection of pruritogens indicated in each figure. Error bars: SEM (n = 6/group). (b) Dose-response curve for alloknesis score elicited by the same pruritogens. (c) Time course of alloknesis for histamine (271 nmol/10 µl), PAR-2 agonist SLIGRL-NH2 (76 nmol/10 µl), PAR-4 agonist AYPGKF-NH2 (146 nmol/10 µl), and saline vehicle. (d) Time course of alloknesis for 5-HT (47 nmol/10 µl), chloroquine (193 nmol/10 µl), and BAM8–22 (50 nmol/10 µl). Adapted from Akiyama et al. (2012a)