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. Author manuscript; available in PMC: 2017 Aug 2.
Published in final edited form as: Handb Exp Pharmacol. 2015;226:219–235. doi: 10.1007/978-3-662-44605-8_13

Table 1.

Protease-related mutant mice with atopic dermatitis-like skin

Mutations Upregulated proteases Subtype of
PARs		 References
Serine protease inhibitor Kazal type 5 KLK5 PAR-2 Briot et al. (2009)
KLK5 KLK5 Not tested Furio et al. (2014)
Cathepsin S Cathepsin S PAR-2 Kim et al. (2012)
Serine protease channel-activating protease-1 Serine protease channel-activating protease-1 PAR-2 Frateschi et al. (2011)