Table 3.
Using different mpMRI score thresholds as the indication for biopsy, the number of patients biopsied higher grade cancers (Gleason score ≥ 7) detected and missed by biopsy strategy per 1000 men are shown. The higher grade cancers missed using the combined biopsy strategy (MRI-targeted + systematic) are those missed due to mpMRI score threshold. The higher grade cancers missed using MRI-targeted biopsy technique include those missed due to mpMRI score threshold and those missed in regions of the prostate not targeted. Higher grade cancers missed on systematic biopsy include those missed due to low mpMRI score and those that were detected only in the cores obtained only using MRI-targeted biopsy.
| MRI Score Threshold | Biopsy Type | Number Biopsied | Biopsies Avoided | Number Reclassified | Number Missed |
|---|---|---|---|---|---|
| All patients | MRI Target + Systematic | 1000 (100%) | 0 (0%) | 350 (35%) | 0 (0%) |
| MRI Score ≥ 3 | MRI Target + Systematic MRI Target Systematic |
655 (66%) | 345 (35%) | 311 (31%) 228 (23%) 277 (28%) |
39 (4%) 121 (12%) 73 (7%) |
| MRI Score ≥ 4 | MRI Target + Systematic MRI Target Systematic |
568 (57%) | 432 (43%) | 286 (29%) 218 (22%) 257 (26%) |
63 (6%) 131 (13%) 92 (9%) |
| MRI Score = 5 | MRI Target + Systematic MRI Target Systematic |
49 (5%) | 951 (95%) | 49 (5%) 44 (4%) 39 (4%) |
301 (30%) 306 (31%) 311 (31%) |
Due to rounding, the number of cancers caught and missed do not always sum up to the number detected based on any mpMRI score. MRI target = 2 cores obtained under visual registration + 2 cores obtained under software registration.