Table 5.

Estimated confidence intervals for the probability of detecting early diseased individuals using TAU/ABETA, FDG and ADAS11 of the ADNI data (sensitivity to fully diseased stage and specificity are assumed to equal to 0.8).

	Confidence Intervals for the test covariates
		BTII		BTP		ELB		GI		BCGI
Biomarkers	${\widehat{P}}_2^{\mathit{\text{NP}}}$	lb	ub	lb	ub	lb	ub	lb	ub	lb	ub
TAU/ABETA	0.1335	0.0052	0.2614	0.0371	0.2685	0.0073	0.3712	-	-	0.0000	0.2104
FDG	0.2011	0.0875	0.3388	0.1001	0.3620	0.0724	0.3716	0.0349	0.3152	-	-
ADAS11	0.5754	0.4806	0.6927	0.4829	0.6834	0.4660	0.6657	-	-	-	-

TAU/ABETA: Ratio of the CSF parameters: protein Tau and protein Aβ₄₂.

FDG: Fluoro Deoxy Glucose.

ADAS11: Alzheimer’s Disease Assessment Scale.

BTII: Confidence interval is computed by the BTII approach.

BTII: Confidence interval is computed by the BTII approach.

ELB: Confidence interval is computed by the ELB approach.

ELP: Confidence interval is computed by the ELP approach.

APV: Confidence interval is computed by the APV approach.

${\widehat{P}}_2^{\mathit{\text{NP}}}$: The nonparametric estimation of P₂ in equ (3).