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. 2017 Aug 2;12(8):e0182420. doi: 10.1371/journal.pone.0182420

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© 2017 Govindaraju et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 6 — A) ROS production was assessed in ARPE-19 cells that were exposed to room-air or CSE (10%) and/or treated with cysteamine (250 μM) or fisetin (40 μM). CSE significantly induced ROS production and treatment with cysteamine (250 μM, p < 0.05) or fisetin (40 μM, p < 0.001) significantly reduced the production of ROS. The cell viability of ARPE-19 cells was assessed by MTS-based proliferation assay (B) or propidium iodide exclusion assay (C, D). Treatment of ARPE-19 cells with CSE (50%) resulted in significantly diminished cell viability (p < 0.001), while cysteamine (250 μM) and fisetin (40 μM) treatment resulted in significant rescue in cell viability and ameliorated the deleterious effects of CSE (p < 0.05). Data is presented as ± SEM. * p < 0.05 *** p < 0.001 with n = 8 samples per experimental group.