Table 2. Positively selected sites under branch-site model for foreground lineages Prob(w>1).

Gene	Lineages
	Mammals	Birds	Birds/Reptiles	Amphibian	Fish
MRPS5	-	-	-	-	-
FOXO3a	-	-	-	435 F 0.983*	442 S 0.983*
				436 G 0.987*	591 S 0.956*
				437 P 0.979*
				463 S 0.984*
				655 N 0.982*
PARP1	-	-	-	146 P 0.991**	72 D 0.966*
				563 V 0.967*	269 K 0.995**
				1011 T 0.987*	293 L 0.978*
				1012 S 0.997**	392 N 0.970*
					606 S 0.965*
					807 D 0.965*
					830 D 0.996**
PARP2	-	-	-(Reptiles)	69 S 0.967*	241 M 0.963*
					319 Q 0.977*
PPARGC1A	-	-	-	-	-
SIRT1	-	-	-	-	-
SIRT2	-	-	216 E 0.997**	-	162 L 0.994**
			246 C 0.976*		249 S 0.958*
					253 K 0.960*
SOD3	-	-	-	-	197 E 0.979*
TP53	-	-	-	-	101 K 0.969*
SIRT6	-	-	-	-	-

Lineages corresponded to branches depicted in Fig 1; “-” indicates no positively selected sites were detected in that branch;

*: P < 0.05;

**: P < 0.001.

Numbers of positively selected sites were amino acid residues at the position of each gene in Human.