Table 3.
Unadjusted regression coefficients of MMSE, IADL, and NPI for each anticholinergic scale and total number of drugs (one model for each covariable)
| Outcome 1: MMSE | Outcome 2: IADL | Outcome 3: NPI | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Covariable | r (95% CI) | Standardized r | p value | R 2 | r (95% CI) | Standardized r | p value | R 2 | r (95% CI) | Standardized r | p value | R 2 |
| ACB | –0.22 (–0.69 to 0.25) | –0.04 | 0.36 | 0.2% | –0.27 (–0.45 to –0.09) | –0.14 | 0.003 | 1.6% | 1.13 (0.04 to 2.21) | 0.10 | 0.04 | 1% |
| ADS | –0.37 (–1.00 to 0.26) | –0.06 | 0.25 | 0.3% | –0.32 (–0.56 to –0.08) | –0.12 | 0.009 | 1.3% | 1.08 (–0.36 to 2.53) | 0.07 | 0.14 | 0.5% |
| ARS | –0.08 (–0.97 to 0.82) | –0.01 | 0.86 | <0.1% | –0.37 (–0.71 to –0.04) | –0.10 | 0.03 | 0.8% | 0.52 (–1.50 to 2.53) | 0.03 | 0.62 | 0.1% |
| Chew’s score | –0.05 (–0.47 to 0.37) | –0.01 | 0.81 | <0.1% | –0.30 (–0.46 to –0.14) | –0.17 | <0.001 | 2.5% | 0.57 (–0.37 to 1.51) | 0.06 | 0.23 | 0.3% |
| Han’s score | –0.68 (–1.34 to –0.02) | –0.10 | 0.04 | 0.7% | –0.37 (–0.62 to –0.12) | –0.13 | 0.004 | 1.6% | 1.85 (0.40 to 3.30) | 0.12 | 0.01 | 1.5% |
| Number of drugs with AC properties | –0.51 (–0.85 to –0.18) | –0.14 | 0.003 | 2% | –0.35 (–0.48 to –0.23) | –0.25 | <0.001 | 6.1% | 1.17 (0.43 to 1.91) | 0.15 | 0.002 | 2.3% |
| Total number of drugs | 0.02 (–0.20 to 0.25) | 0.01 | 0.83 | <0.1% | –0.11 (–0.19 to –0.02) | –0.11 | 0.02 | 1.2% | 0.81 (0.31 to 1.32) | 0.16 | 0.002 | 2.4% |
AC anticholinergic, ACB Anticholinergic Cognitive Burden, ADS Anticholinergic Drug Scale, ARS Anticholinergic Risk Scale, CI confidence interval, IADL Instrumental Activities of Daily Living, MMSE Mini Mental State Examination, NPI Neuropsychiatric Inventory, r Regression coefficient, R² Coefficient of determination