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Impact of CuO NP, CuO MP and CuCl2 on gene expression related to anti-oxidative defense, cell cycle regulation, apoptosis and DNA damage response and repair. BEAS-2B cells or A549 cells were treated with the different copper compounds for 24 h. Shown are log2-fold changes of the relative gene expression in a heat map view from mean values of four determinations derived from two independent experiments (value of control = 0). 20 μg/mL CuO are equal to 252 μM Cu2+. n.d.: not determined
