Table 3. Association of clinical characteristics and metastasis after stratification analysis by plasma LDH levels.
| Negative n = 732 |
positive n = 410 |
Total n = 1142 |
p value | |
|---|---|---|---|---|
| Basic Characteristic | ||||
| Age | ||||
| <45 years 45–60 years >60 years |
60(8.2%) 291(39.8%) 381(52.0%) |
37(9.0%) 172(42.0%) 201(49.0%) |
97 463 582 |
0.608 |
| Gender | ||||
| Male Female |
487(66.5%) 245(33.5%) |
303(73.9%) 107(26.1%) |
790 352 |
<0.05* |
| Histological classification | ||||
| Adenocarcinoma Squamous SCLC Others |
202(27.6%) 404(55.2%) 91(12.4%) 35(4.8%) |
105(25.6%) 204(49.8%) 79(19.2%) 22(5.4%) |
307 608 170 57 |
<0.05* |
| Stages | ||||
| I II III IV |
85(11.6%) 80(11.0%) 203(27.7%) 364(49.7%) |
22(5.4%) 28(6.8%) 101(24.6%) 259(63.2%) |
107 108 304 623 |
<0.001** |
| Smoke status | ||||
| No Yes |
332(45.4%) 400(54.6%) |
160(39.0%) 250(61.0%) |
492 650 |
<0.05* |
| Metastasis | ||||
| Brain | ||||
| No Yes |
662(90.4%) 70(9.6%) |
355(86.6%) 55(13.4%) |
1017 125 |
<0.05* |
| Bone | ||||
| No Yes |
611(83.5%) 121(16.5%) |
309(75.4%) 101(24.6%) |
920 222 |
<0.001** |
| Liver | ||||
| No Yes |
693(94.7%) 39(5.3%) |
347(84.6%) 63(15.4%) |
1040 102 |
<0.001** |
| Adrenal gland | ||||
| No Yes |
705(96.3%) 27(3.7%) |
376(91.7%) 34(8.3%) |
1081 61 |
<0.05* |
| Lymph node | ||||
| No Yes |
325(44.4%) 407(55.6%) |
154(37.6%) 256(62.4%) |
479 663 |
<0.05* |
| Intrapulmonary | ||||
| No Yes |
659(90.0%) 73(10.0%) |
354(86.3%) 56(13.7%) |
1013 129 |
0.059 |
| Pleural | ||||
| No Yes |
639(87.3%) 93(12.7%) |
344(84.0%) 66(16.0%) |
983 159 |
0.112 |
| Mediastinal | ||||
| No Yes |
718(98.1%) 14(1.9%) |
393(95.9%) 17(4.1%) |
1111 31 |
<0.05* |
*p values were calculated using the Chi-square test. (*P<0.05, **P<0.001)