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Survival rates for mice with STZ-induced type 1 diabetes. Low-dose STZ was used to induce type 1 diabetes in 8-week-old male mice. The relative survival rates at 18 weeks post-STZ were normalized to those of nondiabetic control mice in each group. Meprin αβ double-KO mice had a significantly lower 18-week survival rate (40%) when compared to wild-type mice (100%) (p ≤ 0.02). ∗ p ≤ 0.05.
