Table 2. Top twenty coldspots in 2014 and 2016 datasets.
| Mutation coldspot 5’→3’/5’→3’ | Fisher combined p-value for coldspot | Mutation coldspot 5’→3’/5’→3’ | Fisher combined p-value for coldspot |
|---|---|---|---|
| Dataset 2014 | Dataset 2016 | ||
| AAAGA/TCTTT | 3.23E-09 | AAAGA/TCTTT | 9.36858E-09 |
| AAAAA/TTTTT | 5.80E-09 | AAAAT/ATTTT | 1.07478E-08 |
| AGAAA/TTTCT | 6.82E-09 | AAAAA/TTTTT | 1.36135E-08 |
| AAAAT/ATTTT | 1.07E-08 | AGAAA/TTTCT | 1.77502E-08 |
| GAAAA/TTTTC | 1.68E-08 | GAAAA/TTTTC | 4.49683E-08 |
| AAGAA/TTCTT | 3.88E-08 | GAAGA/TCTTC | 6.47074E-07 |
| GAAGA/TCTTC | 6.47E-07 | GGAGA/TCTCC | 1.21713E-06 |
| AGAAG/CTTCT | 1.08E-06 | AAGAA/TTCTT | 1.26841E-06 |
| GGAGA/TCTCC | 1.22E-06 | GGAAA/TTTCC | 3.0346E-06 |
| TGAAA/TTTCA | 1.56E-06 | TGAAA/TTTCA | 3.83943E-06 |
| GGAAA/TTTCC | 1.70E-06 | CAAAA/TTTTG | 4.40191E-06 |
| TGAAG/CTTCA | 3.03E-06 | TGAAG/CTTCA | 8.86768E-06 |
| CAAAA/TTTTG | 4.40E-06 | AGAAG/CTTCT | 1.34215E-05 |
| GAAAT/ATTTC | 4.48E-06 | TCAGA/TCTGA | 1.62237E-05 |
| GAAAG/CTTTC | 1.38E-05 | CAAAG/CTTTG | 2.2854E-05 |
| AAAAC/GTTTT | 1.40E-05 | GAAAG/CTTTC | 2.88886E-05 |
| TCAGA/TCTGA | 1.62E-05 | GAAAT/ATTTC | 2.91218E-05 |
| AGAAT/ATTCT | 1.92E-05 | AGAAT/ATTCT | 4.88009E-05 |
| CAAAG/CTTTG | 2.29E-05 | CAGAA/TTCTG | 5.60054E-05 |
| CAGTG/CACTG | 2.45E-05 | AAACA/TGTTT | 7.23417E-05 |
Motifs containing four or five purine tracks are in bold. Motifs detected in both datasets are in grey field