Table 3. Top twenty hotspots in 2014 and 2016 datasets.
| Mutation hotspot 5’→3’/5’→3’ | Fisher combined p-value for hotspot | Mutation hotspot 5’→3’/5’→3’ | Fisher combined p-value for hotspot |
|---|---|---|---|
| Dataset 2014 | Dataset 2016 | ||
| AGGTA/TACCT | 3.12E-10 | AGGTA/TACCT | 1.24262E-11 |
| TCGCA/TGCGA | 2.69E-08 | TCGCA/TGCGA | 2.6884E-08 |
| ACGGC/GCCGT | 5.51E-05 | CACAG/CTGTG | 2.97136E-06 |
| CGCAG/CTGCG | 7.31E-05 | CCGAG/CTCGG | 2.11333E-05 |
| ACCTG/CAGGT | 0.000101 | CCCAG/CTGGG | 2.24424E-05 |
| CACAG/CTGTG | 0.000158 | ACGGC/GCCGT | 5.50895E-05 |
| CCGAG/CTCGG | 0.000240 | CGCAG/CTGCG | 7.3056E-05 |
| CCGGC/GCCGG | 0.000451 | ACCTG/CAGGT | 0.000101 |
| TCGAA/TTCGA | 0.001007 | CAGTA/TACTG | 0.000287 |
| TGGAA/TTCCA | 0.002042 | CTCAG/CTGAG | 0.000431 |
| AGCCA/TGGCT | 0.002623 | CCGGC/GCCGG | 0.000451 |
| CCGCC/GGCGG | 0.002625 | CCGCC/GGCGG | 0.000482 |
| CTCAG/CTGAG | 0.003514 | GCGAA/TTCGC | 0.000508 |
| CACGA/TCGTG | 0.003707 | ACATG/CATGT | 0.000538 |
| ACATG/CATGT | 0.003755 | CCGAC/GTCGG | 0.000630 |
| CAGTA/TACTG | 0.004126 | TGGAA/TTCCA | 0.000657 |
| CCCAG/CTGGG | 0.004429 | AGCCA/TGGCT | 0.000802 |
| GCGAA/TTCGC | 0.005546 | TCGAA/TTCGA | 0.001007 |
| CCGAC/GTCGG | 0.006022 | ACTCA/TGAGT | 0.001370 |
| ACTCA/TGAGT | 0.007033 | AGGTG/CACCT | 0.002439 |
Motifs containing CpG dinucleotide in the middle are italic