Table 1. Lymphoma/T-leukemia development in secondary recipients.
Cell doses | T-cell lymphoma/leukemia incidence | Latency (days) |
---|---|---|
Experiment #1 | ||
4x105 | 5/5 | 14–18 |
4x104 | 5/5 | 14–20 |
4x103 | 5/5 | 20–24 |
400 | 5/5 | 22–25 |
40 | 2/5 | 35–38 |
Experiment #2 | ||
4x104 | 5/5 | 15–18 |
4x103 | 5/5 | 18–26 |
400 | 5/5 | 24–28 |
40 | 0/5 | |
Experiment #3 | ||
4x104 | 5/5 | 14–16 |
4x103 | 5/5 | 14–20 |
400 | 5/5 | 20–24 |
40 | 1/5 | 34 |
Indicated numbers of lymphoma cells were transplanted into sublethally irradiated WT recipients (n = 5 per group). Lymphoma development in the recipients was monitored. Similar results were obtained in three independent experiments.