Fig 5. Associations between HDBR related gray matter changes and motor behavioral changes.

A) Slices of the MNI brain depicting regions in which gray matter volumetric changes were significantly associated with changes in SOT-5 standing balance performance; Larger GM increases over time in blue areas were associated with better (i.e. smaller decreases or larger increases) standing balance performance. B) Scatterplot of the change in GM volume at the peak significant voxel and the change in balance performance; C) A 3D render of the locations of the two significant areas on the MNI brain. D) Summary of the volume and exact peak voxel coordinates of the two significant clusters. The Harvard-Oxford cortical structural atlas [46] was used for identification of the anatomical regions; MNI = Montreal Neurologic Institute.