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. Author manuscript; available in PMC: 2017 Aug 2.
Published in final edited form as: Neurologist. 2013 Jan;19(1):26–29. doi: 10.1097/NRL.0b013e31827c6c3d

Figure 2.

Figure 2

Brain biopsy - Immunostain for CD68 highlights numerous positive cells consistent with macrophages. The presence of numerous macrophages and relative preservation of axons is suggestive of a demyelinating process (original magnification X200). Brain biopsy - Immunostain for SV40 shows positivity in large nuclei. The presence of SV40 positive nuclei is suggestive of a demyelinating process such as progressive multifocal leukoencephalopathy. SV40 is a DNA virus which belongs to the genus Polyomavirus. Other Polyomaviruses including BK and JC can be associated with kidney disease and demyelinating brain diseases (original magnification X200).