Table 4.

Effects of tumor characteristics (Gleason score and tumor size at histopathology) on sensitivity of each MRI sequence in different prostate zones. With the exception of MRS in the PZ and overall prostate gland, all 4 MRI sequences had significantly higher sensitivity in detecting larger tumors and tumors with Gleason score > 7 (p<0.05 for all comparisons).

Overall Prostate Gland
SENSITIVITY	MRI sequence
	T2W MRI	DCEMRI	MR spectroscopy	DW MRI
Tumor type
Gleason score <=7	0.47 (0.05)	0.27 (0.05)	0.14 (0.04)	0.45 (0.05)
Gleason score > 7	0.8 (0.06)	0.69 (0.08)	0.32 (0.14)	0.74 (0.07)
Size <= 5 mm	0.37 (0.05)	0.13 (0.03)	0.08 (0.03)	0.33 (0.06)
Size > 5 mm	0.68 (0.05)	0.53 (0.07)	0.25 (0.08)	0.64 (0.06)

Peripheral Zone
SENSITIVITY	MRI sequence
	T2W MRI	DCE MRI	MR spectroscopy	DW MRI
Tumor type
Gleason score <=7	0.56 (0.05)	0.30 (0.05)	0.17 (0.04)	0.52 (0.06)
Gleason score > 7	0.85 (0.05)	0.69 (0.09)	0.30 (0.17)	0.74 (0.08)
Size <= 5 mm	0.45 (0.05)	0.15 (0.04)	0.10 (0.04)	0.40 (0.07)
Size > 5 mm	0.75 (0.05)	0.55 (0.07)	0.26 (0.09)	0.68 (0.06)

Central Gland
SENSITIVITY	MRI sequence
	T2W MRI	DCE MRI	MR spectroscopy	DW MRI
Tumor type
Gleason score <=7	0.05 (0.05)	0.12 (0.08)	0 (0)	0.10 (0.07)
Gleason score > 7	0.6 (0.21)	0.7 (0.18)	0.4 (0.23)	0.75 (0.18)
Size <= 5 mm	0 (0)	0.05 (0.05)	0 (0)	0 (0)
Size > 5 mm	0.34 (0.15)	0.44 (0.14)	0.2 (0.13)	0.46 (0.16)

Anterior Peripheral Zone and Central Gland
SENSITIVITY	MRI sequence
	T2W MRI	DCE MRI	MR spectroscopy	DW MRI
Tumor type
Gleason score <=7	0.29 (0.07)	0.18 (0.06)	0.06 (0.03)	0.35 (0.07)
Gleason score > 7	0.76 (0.13)	0.79 (0.12)	0.5 (0.18)	0.84 (0.11)
Size <= 5 mm	0.12 (0.07)	0.07 (0.04)	0.02 (0.02)	0.29 (0.1)
Size > 5 mm	0.57 (0.09)	0.49 (0.1)	0.27 (0.11)	0.59 (0.09)