Fig. 10.

Changes in the ROS, antioxidant enzymes, NO signaling, glutamate, and AchE activities in brains of mice exposed to nano-TiO₂. Mice were treated with nano-TiO₂ suspension or saline solution as indicated through intraperitoneal injection once a day for 14 days. N = 10, * compared to control, P < 0.05; # compared to control, P < 0.01. a Change of ROS (O2-, H2O2, and MDA) in brains of mice exposed to nano-TiO2. b Change of antioxidant enzymes (SOD, CAT, APX, and GSHPx) in brains of mice exposed to nano-TiO2. c Change of NO signaling components (cNOS, iNOS, and NO) in brains of mice exposed to nano-TiO2. d Change of glutamate content and AchE activity in brains of mice exposed to nano-TiO2