Fig. 5.

Ultramicroscopic structure of hepatocytes in mice exposed to nano-TiO₂. Mice were treated with nano-TiO₂ as indicated through gavage once per day for 60 days. The mice in the control group received 0.5% CMC (carboxymethyl cellulose). a Control (×8000). b TiO₂ (5 mg/kg) (×8000). c TiO₂ (10 mg/kg) (×10,000). Arrows indicates mitochondria and vacuoles in mitochondria. d TiO₂ (50 mg/kg) (× 10,000)