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. 2017 Aug 2;12:478. doi: 10.1186/s11671-017-2242-2

Table 2.

Effects of TiO2 of different sizes at different concentration on the growth and development of mouse in vitro embryos (N = 15)

TiO2 concentration VXY diameter CRL (mm) Head length (mm) The number of body sections Malformation rate (%) Death rate (%)
micro-TiO2 0 0
 0.0 4.37 ± 0.08 3.35 ± 0.06 1.45 ± 0.04 30.68 ± 1.65 0 0
 50.0 4.36 ± 0.07 3.34 ± 0.13 1.49 ± 0.12 30.46 ± 1.27 20.0* 0
 100.0 4.46 ± 0.09 3.39 ± 0.08 1.46 ± 0.11 30.82 ± 1.49 33.3* 0
 200.0 4.51 ± 0.11 3.38 ± 0.09 1.46 ± 0.08 30.68 ± 1.29
5–10 nm
 0.0 4.36 ± 0.07 3.34 ± 0.05 1.46 ± 0.05 30.78 ± 1.65 0 0
 50.0 4.37 ± 0.06 3.37 ± 0.8 1.47 ± 0.8 30.63 ± 1.47 0 0
 100.0 4.01 ± 0.24* 2.59 ± 0.28* 1.16 ± 0.08# 22.24 ± 3.47* 20.0* 0
 200.0 3.21 ± 0.28# 2.36 ± 0.49# 1.06 ± 0.12# 17.68 ± 4.22# 33.3* 0
60 nm
 0.0 4.38 ± 0.07 3.35 ± 0.06 1.46 ± 0.06 30.81 ± 1.72 0 0
 50.0 4.37 ± 0.06 3.36 ± 0.05 1.47 ± 0.08 30.63 ± 2.14 0 0
 100.0 3.41 ± 0.34* 2.51 ± 0.32* 1.22 ± 0.18# 24.17 ± 4.61# 6.67 0
 200.0 4.32 ± 0.26 2.29 ± 0.51* 0.96 ± 0.21# 15.36 ± 4.71# 60.0* 0
90 nm
 0.0 4.37 ± 0.07 3.35 ± 0.05 1.46 ± 0.06 30.91 ± 1.67 0 0
 50.0 4.38 ± 0.06 3.38 ± 0.11 1.47 ± 0.08 30.13 ± 1.61 0 0
 100.0 4.09 ± 0.14* 2.89 ± 0.02* 1.19 ± 0.11# 19.17 ± 4.56# 52.7# 6.67
 200.0 3.72 ± 0.21# 2.52 ± 0.21# 1.08 ± 0.15# 14.67 ± 3.57# 74.1# 26.67*

Compared to control; *P < 0.05, # P < 0.01