Table 2.

Summary of Adverse Events While Receiving Treatment, Irrespective of Causality

Adverse Event	Phase IB		Phase II
	N = 30		N = 47
	Number of patients (%)		Number of patients (%)
	All Grades	Grade ≥ 3	All Grades	Grade ≥ 3
Fatigue	19 (63)	6 (20)	17 (36)	11 (23)
Anemia	10 (33)	4 (13)	1 (2)	1 (2)
Nausea/vomiting	9 (30)	1 (3)	3 (6)	2 (4)
Thrombocytopenia	8 (26)	1(3)	5 (11)	0
Neutropenia	7 (23)	7 (23)	6 (13)	3 (6)
Diarrhea	5 (17)	2 (7)	7 (15)	3 (6)
Pleural Effusion	0	0	7 (9)	5 (11)
Peripheral neuropathy	0	0	5 (11)	0
Acute renal failure	0	0	4 (9)	0
Anorexia	0	0	3 (6)	2 (4)
Mucositis	0	0	3(6)	1 (2)
Dyspnea	0	0	1 (2)	1 (2)
Bleeding	0	0	1 (2)	1 (2)
Hypokalemia	0	0	1 (2)	1 (2)
Hemorrhagic shock (death)	0	0	1 (2)	1 (2)
Deep vein thrombosis	0	0	1 (2)	0
Rash	0	0	1 (2)	0
Cardiomyopathy	0	0	1 (2)	0