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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: J Psychopharmacol. 2017 Jul 18;31(8):1078–1087. doi: 10.1177/0269881117715598

Figure 3.

Figure 3

5-HT1B agonist-induced potentiation of methylphenidate (MP)-induced IEG expression in the middle striatum. Mean density values (mean ± SEM) for Zif268 (A), c-Fos (B) and Homer1a expression (C) in rats that received vehicle (V), MP (5 mg/kg), MP plus the 5-HT1B receptor agonist CP94253 (3 or 10 mg/kg; MP+CP3, MP+CP10), CP10 alone, or MP plus fluoxetine (5 mg/kg; MP+FLX) are given for the dorsal (d), dorsolateral (dl), and ventrolateral (vl) sectors on the middle level. CP94253 potentiated MP-induced expression of Zif268 and c-Fos, but not Homer1a, in a dose-dependent manner. This effect was most robust in the lateral sectors. FLX potentiated MP-induced expression of all three IEGs. *P<0.05, **P<0.01, ***P<0.001 vs. V; #P<0.05, ##P<0.01, ###P<0.001 vs. MP (potentiation) and as indicated.

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